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A review of Raman for multicomponent analysis

Authors: 

Sinead J. Barton, Bryan M. Hennelly, Tomas Ward, Katarina Domijan, John Lowry

Publication Type: 
Refereed Conference Meeting Proceeding
Abstract: 
Raman spectroscopy is a powerful tool for analyzing the composition of biological samples in terms of biomolecular content. Over the past two decades there has been considerable interest in the application of Raman to measuring the concentration of the various constituents in a multicomponent mixture. This is achieved by first building a database of the Raman spectra of the individual components in a pure form. Following this a least squares algorithms is applied to find a best fit that accounts for the spectrum of the mixture. The weights returned by a partial least squares algorithm indicate the relative concentration of each component. Of particular interest has been application of the method to estimate the concentration of various analytes in blood and urine samples, including glucose. In this paper we briefly review the subject of multicomponent analysis by Raman Spectroscopy in terms of experimental methodology, limits of measurement, and applications © (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Conference Name: 
Biophotonics: Photonic Solutions for Better Health Care IV
Proceedings: 
Biophotonics: Photonic Solutions for Better Health Care IV
Digital Object Identifer (DOI): 
http://dx.doi.org/10.1117/12.2051769
Publication Date: 
14/04/2014
Conference Location: 
United States of America
Research Group: 
Institution: 
NUIM
Open access repository: 
No